Glycosaminoglycans in therapy of diabetic nephropathy
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منابع مشابه
SCIENCE WATCH Glycosaminoglycans: Use in Treatment of Diabetic Nephropathy
Because diabetic nephropathy occurs in 20 to 40% of patients with diabetes mellitus, it has become one of the most important causes of end-stage renal disease. The latest incidence figures vary from 16% of patients starting with dialysis in The Netherlands (1) to 42% in the United States (2). Diabetic nephropathy has a large impact in terms of associated morbidity and mortality for the individu...
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D iabetic nephropathy, the predominant single cause of ESRD in the developed world (1), is characterized histologically by mesangial matrix expansion and sclerosis, glomerular basement membrane thickening, and hyaline deposits in the glomerular arterioles (2,3). Although the mesangial cells and podocytes are proposed as the major mediators of diabetic nephropathy, diabetic-induced microvasculat...
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Diabetes mellitus is the most common cause of chronic renal disorders and end-stage kidney disease in developed countries. It is the major cause of dialysis and transplantation. Failure in renal function causes wide disorders in the body. Diabetes results in wide range of alterations in the renal tissue. It is believed that early histological changes in diabetic nephropathy are detectabl...
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Angiogenesis has been shown to be a potential therapeutic target for early stages of diabetic nephropathy in a number of animal experiments. Vascular endothelial growth factor (VEGF) is the main mediator for abnormal angiogenesis in diabetic glomeruli. Although beneficial effects of anti-VEGF antibodies have previously been demonstrated in diabetic animal experiments, recent basic and clinical ...
متن کاملRosmarinic Acid Ameliorates Diabetic Nephropathy in Uninephrectomized Diabetic Rats
Objective(s) Oxidative stress plays an important role in diabetic nephropathy pathogenesis. Rosmarinic acid, a plant phenolic compound, was first used as an antioxidant agent for inhibition of diabetic nephropathy. Material and Methods Forty male rats were uninephrectomized from the left flank.The rats were divided in four groups randomly; group one as control, group two diabetic untreatment...
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ژورنال
عنوان ژورنال: Problems of Endocrinology
سال: 1996
ISSN: 2308-1430,0375-9660
DOI: 10.14341/probl12082